NMR-Bio probes proteins

Nuclear Magnetic Resonance (NMR) is a powerful imaging tool. It explores the dynamics, structures and interactions between molecules using proton vibrations. For proteins, excess signals build up and lose their visibility. The NMR-Bio start-up company has developed a technique, designed by researchers at the IBS1Institut de Biologie Structurale (CNRS/CEA/Université Grenoble Alpes) and the Biosciences and Biotechnology Institute of Grenoble (BIG)2CNRS/CEA/Université Grenoble Alpes, to enable selective deuterium-labelling of the molecules to be surveyed. The replacement of 95% of protons by deuterium atoms, which are not detected by NMR, makes it possible to study proteins up to 30 times more complex than before.